Myosin light chain kinase mediates intestinal barrier disruption following burn injury.
BACKGROUND: Severe burn injury results in the loss of intestinal barrier function, however, the underlying mechanism remains unclear.Myosin light chain (MLC) phosphorylation mediated by MLC kinase (MLCK) is critical to the pathophysiological regulation of intestinal barrier function.We hypothesized that the MLCK-dependent MLC phosphorylation mediat